Bimo Sasono and Heri Suroto and Dwikora Novembri Utomo and Aulanni'am and Hari Basuki Notobroto and Damayanti Tinduh and Fedik Abdul Rantam (2019) RUNX2 and SOX9 Expression on Chondrocyte Hypertrophy Formation in Post-Menopausal Osteoarthritis Mechanism (An Experimentation on Rat Model). The Indian Veterinary Journal, 96 (10). pp. 41-44. ISSN 09749365

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Abstract

In osteoarthritis post-menopause, decreasing estrogen in uenced formation of chondrocyte hypertrophy. This study would explain role of RUNX2 and SOX9 to chondrocyte hypertrophy formation in decreasing estrogen condition. Fifty four rats were divided into six groups. Level of 17 β estradiol and TGF-β were examined by ELISA. SOX9 and RUNX2 used immunohistochemistry. Histopathology for chondrocyte hypertrophy. Level of 17 β estradiol and SOX9 on treatment group decreased signi cantly, TGF-β and RUNX2 increased signi cantly. Chondrocyte hypertrophy increased significantly in treatment group. The decreasing of 17β estradiol level caused increasing hypertrophy Chondrocyte through increasing level of TGF-β and RUNX2.

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