Sholahuddin Rhatomy and Dwikora Novembri Utomo and Cita Rosita Sigit Prakoeswa and Fedik Abdul Rantam and Heri Suroto and Ferdiansyah Mahyudin (2021) Ligament/Tendon Culture under Hypoxic Conditions: A Systematic Review. Advanced Pharmaceutical Bulletin. pp. 1-10. ISSN 22517308

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Abstract

The hypoxic environment is a substantial factor in maintenance, proliferation, and differentiation of the cell cultures. Low oxygen is known as a potent chondrogenesis stimulus in stem cells that is important for clinical application and engineering of functional cartilage. Hypoxia can potentially induce angiogenesis process by secretion of cytokines. This systematic review goal is to discover the effect of hypoxic condition on tendon/ ligament culture and the best oxygen level of hypoxia for in vitro and in vivo studies. We included 21 articles. A comprehensive review of this database confirms that the hypoxic condition is a substantial factor in the maintenance, proliferation, and differentiation of ligament/tendon cultures. Cell proliferation in the severe hypoxic (oxygen concentration of 1%) group at 24 h postcultivation was considered significant, but cell proliferation was markedly inhibited in the severe hypoxic group after 48 h.

Item Type:	Article
Uncontrolled Keywords:	Hypoxic condition, ligament, tendon, culture
Subjects:	R Medicine > R Medicine (General) R Medicine > RD Surgery > RD701-811 Orthopedic surgery
Divisions:	01. Fakultas Kedokteran > Orthopaedi dan Traumatologi
Creators:	Creators NIM Sholahuddin Rhatomy UNSPECIFIED Dwikora Novembri Utomo NIDN8897700016 Cita Rosita Sigit Prakoeswa NIDN8865610016 Fedik Abdul Rantam NIDN0010035907 Heri Suroto NIDN8802630017 Ferdiansyah Mahyudin NIDN8890010016
Depositing User:	arys fk
Date Deposited:	17 Jun 2021 06:55
Last Modified:	17 Jun 2021 06:55
URI:	http://repository.unair.ac.id/id/eprint/107973
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