Jehan Wiendrati Roostarini and Soebagijo Adi Soelistijo and Hermina Novida and Ari Sutjahjo and Sony Wibisono and Jongky Hendro Prajitno and Hermawan Susanto and Muhammad Miftahussurur and Askandar Tjokroprawiro (2019) Lipoprotein (a) and Arterial Stiffness in Patients with Diabetes Mellitus. New Armenian Medical Journal, 13 (1). pp. 74-78. ISSN 18290825

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Abstract

Background: Type 2 Diabetes Mellitus (T2DM) increases morbidity and mortality of cardiovascular disease including atherosclerotic complications. The pathogenesis of atherosclerosis in T2DM is primarily due to changes in lipid profiles and lipoproteins. High levels of lipoprotein (a)/Lp (a) are known to be a risk factor for atherosclerosis. However, the correlation between Lp (a) levels and arterial stiffness has not been widely known. Objectives: To determine the correlation between Lp (a) and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) in patients with T2DM in Endocrine Metabolic and Diabetes Unit of RSUD Dr. Soetomo Teaching Surabaya. Methods: The cross-sectional observational analytical research was conducted on T2DM patients aged ≥45 in Endocrine Metabolic and Diabetes Unit of Dr. Soetomo Teaching Hospital from June 2015 to August 2015. T2DM was determined based on the American Diabetes Association (ADA) 2014 criteria. Lp (a) was measured using Latex agglutination testand arterial stiffness was measured by baPWV. Results: Among 39 T2DM patients, 25.6% had Lp (a) ≥30 mg/dL with mean of Lp (a) levels of 21.66±18.67 mg/dL and 94.9% of patients had the mean of baPWV of 16.61±2.57 cm/s. The correlation result of Lp (a) and baPWV showed p = 0.88 and r = 0.026. Conclusion: There was no correlation between Lp (a) and arterial stiffness (using baPWV measurement) in patients with T2DM.

Item Type:	Article
Uncontrolled Keywords:	lipoprotein (a), arterial stiffness, diabetes mellitus
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Jehan Wiendrati Roostarini UNSPECIFIED Soebagijo Adi Soelistijo NIDN8837500016 Hermina Novida NIDN0012117705 Ari Sutjahjo NIDN0010025107 Sony Wibisono NIDN8827800016 Jongky Hendro Prajitno NIDN0011117211 Hermawan Susanto NIDN0002037209 Muhammad Miftahussurur NIDN0029097909 Askandar Tjokroprawiro NIDN8808940017
Depositing User:	arys fk
Date Deposited:	03 Jul 2021 15:23
Last Modified:	03 Jul 2021 15:23
URI:	http://repository.unair.ac.id/id/eprint/108330
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