Muhammad Miftahussurur, - and Denada Aisyah Syalini, - and Iswan Abbas Nusi, - and Ummi Maimunah, - and Hartono Kahar, - and Poernomo Boedi Setiawan, - and Herry Purbayu, - and Ulfa Kholili, - and Budi Widodo, - and Husin Thamrin, - and Amie Vidyani, - and Gontar Alamsyah Siregar, - and Yudith Annisa Ayu Rezkitha, - and Titong Sugihartono, - (2020) Diagnostic value of Helicobacter pylori serum serology using immunochromatography method with current infection marker compared to histopathology in dyspeptic patients. EurAsian Journal of BioSciences, 14 (1). pp. 1869-1876. ISSN 13079867

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Abstract

Introduction: Examination using Outer Membrane Protein as a marker of active Helicobacter pylori Current Infection Marker (CIM) infection has now been developed. However, the accuracy of CIM is still unknown. This study aimed to analyze the diagnostic value of serum serology using CIM compared to histopathological examination as the gold standard for diagnosing the presence of H. pylori infection in dyspepsia patients. Methods: This study involved fifty-two subjects with dyspepsia. Endoscopic, biopsy, and histopathological examination with modified-giemsa staining as gold standard and serological examination using immunochromatography method with CIM (AssureR, Singapore) had been done to all subjects of this study. Results: Pre-test probability of H. pylori infection was 17.3%. Most of subjects infected with H. pylori were male with average age of 53.89±7.75 years old. Most of endoscopic features of subjects infected with H. pylori were erosive gastritis. The sensitivity, specificity, positive predictive value, negative predictive value of CIM were 22.2%, 95.3%, 50%, and 85.4%, respectively. The positive likelihood ratio, negative likelihood ratio, and accuracy of CIM were 4.8, 0.8, and 82.7%, respectively. Conclusion: Serum serology using immunochromatography with CIM cannot replace histopathology for diagnosis of Helicobacter pylori current infection in dyspeptic patients.

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