Sony Wibisono (2015) Metabolic Syndrome, Obesity and Testosterone deficiency Why it's Happen? What's the Correlated? In: Proceeding The 57th Quadruple Symposium. Pusat Diabetes dan Nutrisi RSUD Dr. Soetomo, Surabaya, Surabaya, pp. 174-180. ISBN 978-602-71520-1-4

	Text (Artikel) C-37_compressed.pdf Download (1MB)
	Text (Peer Review) C-37 KADEP.pdf Download (2MB)

Abstract

Over the last three decades, it has become apparent that testosterone plays a significant role in glucose homeostasis and lipid metabolism. The metabolic syndrome is a clustering of risk factors predisposing to diabetes mellitus type 2, atherosclerosis and cardiovascular morbidity and mortality. The main components of the syndrome are visceral obesity, insulin resistance, glucose intolerance, raised blood pressure and dyslipidemia (elevated triglycerides, low levels of high density lipoprotein cholesterol), and a pro-inflammatory and thrombogenic state. Cross sectional epidemiological studies have reported a direct correlation between plasma testosterone and insulin sensitivity, and low testosterone levels are associated with an increased risk of type 2 diabetes mellitus, dramatically illustrated by androgen deprivation in men with prostate carcinoma. Lower total testosterone and sex hormone-binding globulin (SHBG) predict a higher incidence of the metabolic syndrome. There is evidence that hypotestosteronemia should be an element in definition of the metabolic syndrome since low levels of testosterone are associated with or predict the development of the metabolic syndrome and of diabetes mellitus.

Actions (login required)

View Item