FITRIA SILVIANA, 050710309 (2012) PENGARUH JENIS CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CHITOSAN (dibuat dengan metode orifice-ionic gelation). Skripsi thesis, UNIVERSITAS AIRLANGGA.
|
Text (ABSTRAK)
gdlhub-gdl-s1-2012-silvianafi-22514-ff3841-k.pdf Download (333kB) | Preview |
|
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text (FULLTEXT)
gdlhub-gdl-s1-2012-silvianafi-18941-ff3841-p.pdf Restricted to Registered users only Download (1MB) | Request a copy |
Abstract
Microparticles of ketoprofen could be developed to avoid gastrointestinal irritation. The aim of research is to investigate effect of chitosan with different viscosity (Low : 19 cps ; Medium : 44 cps) on physical characteristics and in vitro release of ketoprofen-chitosan. Microparticles of ketoprofen were prepared by orifice-ionic gelation method using 21G syringe. The obtained microparticles was evaluated for its morphology and particle size, drug content, and drug release in phosphate buffer media pH 6,8. The result showed that as the chitosan viscosity increased, the mean partcle size of microparticles decreased, with smoother surface and spherical shape, encapsulation efficiency increased.. Drug release in phosphate buffer media pH 6,8 decreased as the chitosan viscosity increased.
| Item Type: | Thesis (Skripsi) | ||||||
|---|---|---|---|---|---|---|---|
| Additional Information: | KKB KK2 FF 384 11 Sil p | ||||||
| Uncontrolled Keywords: | CHITOSAN | ||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | ||||||
| Divisions: | 05. Fakultas Farmasi | ||||||
| Creators: |
|
||||||
| Contributors: |
|
||||||
| Depositing User: | Turwulandari | ||||||
| Date Deposited: | 02 Feb 2012 12:00 | ||||||
| Last Modified: | 09 Jun 2017 19:57 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/10898 | ||||||
| Sosial Share: | |||||||
Actions (login required)
 |
View Item |