Marta Lastijani Sigit, - and Mahrus A. Rahman, - and I Ketut Alit Utamayasa, - (2020) Comparison of the effects of giving captopril and valsartan in cases of heart failure for people with congenital heart disease. EurAsian Journal of BioSciences, 14 (2). pp. 3463-3467. ISSN 13079867

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Abstract

Background: Congenital Heart Disease (CHD) has a prevalence ranging from 6 to 10 per 1000 live births, with an average of 8 out of 1000 live births. One of the pathological consequences of CHD is heart failure. Therapy for heart failure in CHD is still unsatisfactory. Purpose: Comparing the effect of captropyl and valsartan on clinical improvement, echocardiography, electrocardiography, and chest radiograph in cases of heart failure with congenital heart disease left to right. Method: The study design was Randomized Control Trial (RCT) by giving Double Blind Study treatment. There are 2 treatment groups, namely X1 by giving captopril and X2 by giving valsartan. Data were analyzed by Paired T-Test, T-Test, Mann-Whitney Test, and 5% significance. Result: The results of statistical analysis showed a significant change in the PHFS score, but it was not significant when compared between the two treatment groups. Increased LVEDV and LV dimension less after giving captopril than valsartan. There was an increase in LVEF after captopril administration although it was not significant when compared to the valsartan group. The reduction in CTR in the valsartan group was significant and the mean reduction in CTR in the valsartan group was greater than in the captopril group. Conclusion: Clinical, echocardiographic, electrocardiographic, and chest radiograph improvement after adding captopril and valsartan, but better improvements were obtained in valsartan administration than captopril.

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