Astika, Yuli (2021) Evaluasi Ratio PaO2/FiO2 (P/F Ratio) Sebagai Faktor Risiko Hipoksemia Terhadap Mortalitas Sepsis Pada Anak Yang Dirawat Di RSUD Dr. Soetomo. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Septicemia is a complex and multifactorial syndrome that occurs due to the body's response to infection, where the response tends to be detrimental, dangerous or destructive. Untreated septicemia will progress to severe septicemia. Until now, research on P/F ratio as a risk factor for hypoxemia to septicemia mortality has not been widely conducted. This study was conducted to evaluate the P/F ratio as a risk factor for hypoxemia against septicemia mortality in children. Methods: This observational analytic study with a prospective cohort design to analyze the role of the PaO2/FiO2 ratio (P/F ratio), as a risk factor for septicemia mortality in children admitted to Dr. Soetomo Hospital. The research subjects were 36 septicemia patients who were treated in the Pediatric Intensive Care Unit (PICU), emergency department, pediatric ward in Dr. Soetomo Hospital Surabaya. The PaO2/FiO2 ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded on medical records and calculated manually. The output is categorized into survival and non-survival. The cut off value is obtained using the receiver operating characteristic (ROC) curve. Statistical analysis used the Chi-Square test, the significance value of p < 0.05. Result : A total of 36 septicemia divided 18 children non-survival and 18 children survival met the inclusion and exclusion criteria. The PaO2/FiO2 ratio has an area under the curve (AUC) of 0.83 (95% CI 0.71 – 0.95) with a cut off of 226 (RR 6.9 ; 95% CI 1.719 – 27.957; p = 0.005) with a sensitivity of 72, 70%; specificity 72.20%; PPV 76.19%; NPV 68.42%. The mean PaO2/FiO2 ratio in the non-survival group was significantly lower than the survival group, namely 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p = 0.005. The mean PaO2/FiO2 ratio in septicemia non-survival statistically different from the PaO2/FiO2 ratio in septicemia survival (p = 0.005). Conclution: The PaO2/FiO2 ratio can be a risk factor for hypoxemia against septicemia mortality

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