Azhar Hanafi, - and Amaq Fadholly, - and Budi Utomo, - and Sri Agus Sudjarwo, - and Muchammad Yunus, - and Mas’ud Hariadi, - and Djoko Legowo, - (2020) Effects of Moringa oleifera L. Leaves extract on leydig and sertoli cells induced high Temperature on Rattus norvegicus. Research Journal of Pharmacy and Technology, 13 (7). pp. 3361-3366. ISSN 0974-3618, 0974-360X (Online)

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Abstract

The aim of this study was to investigate the protective effect of Moringa oleifera leaves extract on the number of leydig and sertoli cells on Rattus norvegicus due to induced high temperature. Twenty five male rat were divided into five groups, five rat for each group and administered through intragastric gavage with differents treatments for 21 days. The treatment groups were C–(NaCMC 1% 1ml), C+ (NaCMC 1% 1ml + high temperature induction), T1, T2, and T3 (100, 200, and 400mg/kg bw Moringa oleifera Lam leaves ethanol extract respectively+high temperature induction). The high temperature induction was 40°C for one hour. The observation was done by examined the histopathological changes on the numbers of Leydig and Sertoli cells. The research showed that Moringa oleifera leaves extract could protect the leydig and sertoli cells in rat testes from destructive effect of high temperature induction. Keywords: Moringa oleifera, Leydig, Sertoli, Testes

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