Synthesis and Brine Shrimp Bioassay of Chalcone and Its Two Methoxy Derivatives

Melanny Ika Sulistyowati, - and Kholis Amalia Nofianti, - and Suzana, - and Tutuk Budiati, - (2013) Synthesis and Brine Shrimp Bioassay of Chalcone and Its Two Methoxy Derivatives. International Journal of Pharmaceutical and Chemical Sciences, 2 (2). pp. 719-724. ISSN 2277-5005

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Abstract

Chalcone and its two methoxy derivatives have been synthesized by a simple Claisen-Schmidt condensation in presence of NaOH 60%. The reactions were carried out at room temperature for about 15 -105 minutes and provided the desired compounds in about 73-96% yields. The structure of the compounds was confirmed by 1H-NMR, 13C-NMR, IR, MS and UV-vis spectroscopic methods. Furthermore, all the synthesized compounds were examined their cytotoxic action by BST method (brine shrimp lethality test) and expressed as toxic compound.

Item Type: Article
Uncontrolled Keywords: chalcones, aldol condensation, synthesis, brine shrimp test, cytotoxic.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Creators:
CreatorsNIM
Melanny Ika Sulistyowati, -NIDN0005058201
Kholis Amalia Nofianti, -NIDN0025118601
Suzana, -NIDN0027096504
Tutuk Budiati, -NIDN0026014804
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Sep 2021 04:11
Last Modified: 22 Dec 2021 00:38
URI: http://repository.unair.ac.id/id/eprint/110143
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