Esti Hendradi and Faddlun Nur Hidayati and Tristiana Erawati (2021) Characteristic of Nanostructured Lipid Carrier (NLC) Diclofenac Diethylammonium as Function of Ratio of Glyceryl Monostearate and Caprylic Acid. Research Journal of Pharmacy and Technology (RJPT), 14 (3). pp. 1699-1704. ISSN 0974-3618

	Text (FULLTEXT) C-02 Fulltext.pdf Download (3MB)
	Text (PEER REVIEW) C-02 Peer Review.pdf Download (585kB)
	Text (SIMILARITY) C-02 Similarity.pdf Download (1MB)

Abstract

The present study investigated the characteristics of diclofenac diethylammonium-containing NLC as function of ratio of glyceryl monostearate (GMS) and caprylic acid (mygliol 80) of 65:35; 75:25 and 85:15. There were three formulas and the composition of each formula were diclofenac diethylammonium 1.16%; glyceryl monostearate and caprylic acid with ratio (65:35; 75:25 and 85:15); Tween 80 5%; and phosphate buffer pH 6.0 ± 0.1 as dispersion medium. The result showed that each formula had different characteristic of particle size and efficiency entrapment. Particle size was analized by DelsaTMNano, F I (65:35) had particle size 134.467 ± 26.601 nm with PI 11.776; F II (75:25) had particle size 2252.233 ± 727.370 nm with PI 0.348; and F III (85:15) had particle size 1500.867 ± 219.673 nm with PI 0.260. The present Entrapment Efficiency (EE) carried out by centrifuge method and result of F I, F II and F III were 88.342 ± 0.52%, 73.764 ± 0.511% and 70.754 ± 0.665%, respectively. The result was analyzed by statistic with ANOVA one-way method with degree of confident 95% (a = 0.005). Research result revealed that the best characteristics of diclofenac diethylammonium in terms of particle size and % Entrapment Efficiency (EE) was F I with ratio of GMS and caprylic acid (mygliol 80) 65:35.

Actions (login required)

View Item