Pratiwi Soesilawati, - and Agnes P.N, - and M.Alwino Bayu P., - and Yuliati Yuliati, - and Noor Hayaty AK., - (2021) Regulating The Fibroblast Growth Into Critical Size Mandibular Bone Defect via Demineralized Dentin Material Membrane Implantation. Internasional Journal of Pharmacetucal Research., 13 (1). pp. 3758-3763. ISSN 09752366

	Text (ARTIKEL) Regulating The Fibroblast Growth Into Critical Size.pdf Download (656kB)
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	Text (VALIDASI) 7. Regulating The firboblast growth into critical size mandibular bone defect via demineralized dentin material membrane implantation.pdf Download (2MB)
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Abstract

Mandibular bone damage due to trauma, pathological conditions, and congenital disease create large bone defect or critical size defect that will not heal for life without intervention or healing with forming fibrous encapsulation which is undesirable. Therefore, a Guided Bone Regeneration (GBR) procedure can be performed. Human dentin and bone, as well as bovine dentin, are known to have a very high chemical composition. The researchers considered bovine dentin as an alternative GBR membrane material, namely Demineralized Dentin Material Membrane (DDMM). This research aims to measure the amount of fibroblast after DDMM implantation on a mandibular bone defect. Twenty four rats used as samples. Mandibular bone defect 5x5 mm was made. In the control group defect were not applied membrane, and in the experimental group, the defect was applied DDMM. Six samples were sacrificed on 7, and 14 days post-operation for histology examination using Hematoxylin Eosin (HE) staining. The amount of fibroblast was counted and statistically analyzed using Independent T-test with significance being p<0.05. There were no significant differences in the amount of fibroblast after implantation on day 7, and there were significant differences in the amount of fibroblast after implantation on day 14. This result suggests that DDMM implantation is promising to decrease the number of fibroblasts in bone defects and potentially increase bone regeneration.

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