Hendrik Setia Budi, - and Pratiwi Soesilawati, - and Mitha Jati Wirasti, - (2020) Antibacterial Activity of Sappan Wood (Caesalpinia sappan L. )against Aggregatibacter actinomycetem comitans and Porphyromonas gingivalis. Systemic Reviews Pharmacy, 11 (3). pp. 349-353. ISSN 0976-2779

	Text (ARTIKEL) Antibacterial Activity of Sappan Wood.pdf Download (403kB)
	Text (SIMILARITY) 15.Antibacterial Acvtivity of Sappan Wood (Caesalpinia sappan L.) against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.pdf Download (1MB)
	Text (VALIDASI) 15. Pratiwi (Antibacterial ) 15.pdf Download (914kB)
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Abstract

The aim of this study was to find the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of sappan wood ethanol extract (Caesalpinia sappan L.) toward the growth of A.actinomycetemcomitans and P. gingivalis. The randomized post test only control group design was applied to this study. The sappan wood ethanol extract was conducted with maceration method using 96% ethanol. Diluted to 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, and 0.39% concentration. The MIC and MBC values of sappan wood ethanol extract toward A. actinomycetemcomitans and P. gingivalis was then known via the evaluation for Colony Forming Units (CFUs) In MH medium. The MIC and MBC of sappan wood ethanol extract toward A. actinomycetemcomitans and P. gingivalis was at 1.56% and 3.125% concentration. The ethanol extract of sappan wood reduces the number of bacterial colonies significantly at p=0.00. This study concluded that the growth of A. actinomycetemcomitans and P.gingivalis can be inhibited by sappan wood ethanol extract (Caesalpinia sappan L.) at MIC 1.56% and MBC 3.125% concentration.

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