Peran TGF- 1 sebagai Regulator Switching Isotype sekresi sIgA Saliva Repository

Peran TGF- 1 sebagai Regulator Switching Isotype sekresi sIgA Saliva

Pratiwi Soesilawati, - and Harianto Notopuro, - and Istiati Soehardjo, - and Afaf Baktir, - (2011) Peran TGF- 1 sebagai Regulator Switching Isotype sekresi sIgA Saliva. Jurnal Biosains Pascasarjana Univ Airlangga, 13 (3). pp. 137-141. ISSN 1412-1433

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Abstract

IgA Isotype switching requires the induction of TGF-fSl to regulate transcriptional activity. Disturbances in the differentiation of B cells can occur because of an increasing or decreasing in expression of TGF-fSl. This difference causes the differentiation of B cells disrupted because TGF-fSl play a role in DMA re-arrangement for isotype switching in B cells, causing changes in membrane-bound atitibody IgM became membrand-bound antibody IgA. This Study was aimed to identity and coralabe between slgA with TGF beta. This research was conducted through the 30 samples from the case group with slgA levels > 300 ng/ml and 30 samples from the control group with slgA levels < 300 ng/ ml. Gingival tissues obtained during the extraction of decidous teeth. Gingival tissue was inserted into a solution of 10% bufferedformalin. Preparation of histological preparationsfollowed by immunohistochemical staining procedure using monoclonal antibody anti-TGF-fil. This result showed that statistical tests of TGF-fil in the case group contained an average of 26% of the entire field of view of the lamina propria. Average in the control group by 5 7% of the entire field of view of the lamina propria. Data on the number ofTGF-fil in the case and control groups are normally distributed. The results of the analysis by t test found significant differences in the mean number ofTGF-fil in the case and control groups (p = 0.000). There is a strong correlation between TGF-fil and slgA. Decreased ofTGF-fil expression associated with decreased activation in the slgA isotype switching, and vice versa.

Item Type:

Article

Subjects:

R Medicine
R Medicine > RK Dentistry

Divisions:

02. Fakultas Kedokteran Gigi > Oral Medicine

Creators: