Roedi Irawan, - and Nur Aisiyah Widjaja, - and Meta Herdiana Hanindita, - and Meity Ardiana, - and Rendi Aji Prihaningtyas, - (2020) The relations of TNF-α, CRP, and lipid profile with carotid intima-media thickness (CIMT) in obese adolescents. Indian Journal of Public Health and Development, 11 (4). pp. 325-331. ISSN 0976-5506

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Abstract

Background: Obesity is a health problem, causes serious complications. The mechanism of fat accumulation in the initial process of atherosclerosis is still unclear. The process occurs due to chronic inflammation where the indicator of atherosclerosis that related to inflammatory processes, such as levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α)in the blood are higher in children with obesity. Purpose: To examine the relationship of TNF-α, hsCRP and lipid profile with CIMT in obese adolescents. Method: A cross sectional study was conducted on obese adolescents in Dr. Soetomo Hospital Child Health Unit from January until September 2018. Measurements of TNF-α, hsCRP and lipid profile were examine using ELISA method. CIMT was obtained through carotid ultrasound. TNF-α correlation, hsCRP and lipid profile with CIMT were analyzed using Pearson and Spearman Rho with significant value of P<0.05. Logistic regression analysis was carried out to determine the effect of cardiovascular disease risk factors on CIMT. Result: 59 adolescents with central obesity were obtained, consisting of 32 (54.2%) boys and 27 (45.8%) girls. Total of 38 (64.4%) adolescents with dyslipidemia. There was no correlation between TNF-α, hsCRP, lipid profile and CIMT. The diameter of common carotid artery had a positive correlation with hsCRP (r=0.284;P=0.029). In girls, hsCRP had a positive correlation with the diameter of the left common carotid artery (r = 0.533; P=0.004). This correlation was not found in boys. Conclusions: There was no correlation between TNF-α, hsCRP, lipid profile and CIMT.

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