Amaq Fadholly, - and Arif N. M. Ansori, - and Viol D. Kharisma, - and Jola Rahmahani, - and Martia R. Tacharina, - (2021) Immunobioinformatics of Rabies Virus in Various Countries of Asia : Glycoprotein Gene. Research J. Pharm. And Tech, 14 (2). pp. 883-886. ISSN 0974-3618, 0974-360X (Online)

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Abstract

he purpose of this study was to analyze the genomic information of the glycoprotein gene of rabies virus (RABV) in several countries of Asia. The genomics information of vaccine virus strain and some local isolates were retrieved from GeneBank® (National Center for Biotechnology Information, USA). Ten genomics informations are consist of ERA vaccine virus, two viruses from Indonesia, a virus from Myanmar, India, Nepal, South Korea, Japan, Sri Lanka, and Iran. This bioinformatics process the ten genomics data in order to find pattern in 1,575 bp of glycoprotein gene of RABV. In conclusion, this study have revealed the data of homology, B-cell epitope prediction, genetic distance, and molecular phylogenic analysis of RABV in various countries of Asia. We indicated that the glycoprotein, the immunogenic surface protein of RABV, has important part for vaccine design Keywords: Bioinformatics Lyssavirus glycoprotein rabies vaccine

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