Iqbal Laksana, - and Purwo Sri Rejeki, - and Lilik Herawati, - and Mohammad Anam Al Arif, - and Indrayuni Lukitra Wardani, - (2021) High-Fat Diet Increases Serum Hdl, But Not For Ldl And Hdl/Ldl Ratio In Mice. Folia Medica Indonesiana, 57 (2). pp. 28-31. ISSN 2355-8393

	Text (Artikel) High-Fat Diet Increases Serum Hdl, But Not For Ldl And Hdl Ldl Ratio In Mice.pdf Download (236kB)
	Text (Similarity) High-Fat Diet Increases Serum Hdl, But Not For Ldl And Hdl Ldl Ratio In Mice.pdf Download (944kB)
	Text (Peer Review) Peer Review Final 16.pdf Download (1MB)

Abstract

The use of a ketogenic diet with an increased proportion of fat is rampant lately, both as a therapy or even lifestyle. The use of a ketogenic diet is feared to cause dyslipidemia. It will also lead to atherosclerosis and thrombosis. This study aimed to determine the effect of a high-fat diet on HDL, LDL, and HDL/LDL ratio in mice. Thirty male Mus Musculus, 2-3 mo, 15-25 g divided into five groups diet. K1 (12% fat, 20% protein, 62% carb), K2 (30% fat, 60%protein), K3 (45% fat, 45% protein), K4 (60% fat, 30% protein) and K5 (75% fat, 15% protein) for 4 weeks. Feed and water by adlibitum. Blood for serum was taken from the ventricle, while in the measurement of HDL serum level, the LDL used ELISA. Normality of data analyzed by Shapiro Wilk, and homogeneity by Levene test. HDL serum was analyzed using equality test followed by Games Howell, LDL serum and ratio of HDL/LDL was tested by ANOVA followed by LSD with significance 0,05. HDL serum in K1 (62,50±9.94) mg/dL, K2 (78,40±18,76) mg/dL, K3 (79,00±3,81) mg/dL, K4 (80,00±2,16) mg/dL, and K5 (83,50±5,62) mg/dL with p<0,05 in K1, K2 to K3, K4 and K5. LDL serum in K1 (21,67± 4,80) mg/dL, K2 (23,00±12,70) mg/dL, K3 (18,40±4,34) mg/dL, K4 (24,00 ±1,83) mg/dL and K5 (22,00 ± 4,08) mg/dL with p>0,05. Ratio HDL/LDL K1 (3,01±0,91), K2 (4,10±1,86), K3 (4,53±1,5), K4 (3,35±0,34), and K5 (3,96 ± 1,25) with p>0,05.

Item Type:	Article
Uncontrolled Keywords:	high fat diet, mice, HDL, LDL, HDL/LDL ratio
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Faal
Creators:	Creators NIM Iqbal Laksana, - UNSPECIFIED Purwo Sri Rejeki, - NIDN0012067503 Lilik Herawati, - NIDN0014037509 Mohammad Anam Al Arif, - UNSPECIFIED Indrayuni Lukitra Wardani, - NIDN0010015908
Depositing User:	arys fk
Date Deposited:	27 Oct 2021 06:37
Last Modified:	16 Mar 2022 00:55
URI:	http://repository.unair.ac.id/id/eprint/111704
Sosial Share:

Actions (login required)

View Item