Syahrani, Septiana, - (2021) Studi Penggunaan Suplemen Kalium Pada Pasien Hipokalemia Yang Mendapat Terapi Kalium Intravena. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Hypokalemia is a state of blood potassium concentration below 3,5 mEq/L which is caused by a decrease in the total body potassium amount or a disturbance in the movement of potassium ions into cells. This study aims to determine the pattern of use of potassium therapy in hypokalemia patients receiving intravenous potassium therapy. The data obtained from previous studies related to the use of intravenous potassium therapy for hypokalemia patients at Hospital X for the period November 2015-September 2017. 41 patients who met the inclusion criteria were classified into three category hypokalemia, mild hypokalemia (4,9%), moderate hypokalemia (61%) and severe hypokalemia (34,1%). Types of intravenous potassium were potassium infusion A (23,8%), potassium infusion B (45,3%), potassium infusion C (7,1%) and potassium infusion D (23,8%). The rate of potassium infusion given was potassium infusion A 1,7 mEq/hour, potassium infusion B 4,2 mEq/hour, potassium infusion C 1,2 mEq/hour and potassium infusion D 2,5 mEq/hour. The success of hypokalemia correction was achieved in 46,3% (19 patients) and the unsuccessful correction was achieved in 53,7% (22 patients). Factors that affect the increase in potassium concentration are the therapeutic dose and the rate of potassium infusion, while the type of intravenous potassium supplementation has no effect on the increase in potassium. It can be concluded that the use of hypokalemia therapy is in accordance with the clinical condition of the patient and the guidelines for the management of hypokalemia therapy. 1. Aboujamous, H, T Walton, and J J Doran. 2016. Evaluation of the Change in Serum Potassium Levels after Potassium Administration. J Clin Nephrol Ren Care 2: 13. 2. Alaydrus, Syafika, and Natalia Toding. 2019. Pola Penggunaan Obat Hipertensi Pada Pasien Geriatri Di Rumah Sakit Anutapura Palu Periode 08 Juli-08 Agustus 2019. Jurnal Mandala Pharmacon Indonesia 5(02): 65–73. 3. Andayani, Novita, Fitri Andriani, and Soraya Rezeki. 2019. Hubungan Antara Pemakaian Penambahan Antikolinergik Pada Beta-2 Agonis Dengan Kejadian Hipokalemia Pada Pasien Penyakit Paru Obstruktif Kronik Eksaserbasi Di RSUDZA Banda Aceh. Medicus Darusalam 1(2): 77–83. 4. Aninditha, T, F Sitorus, and T A S Ranakusuma. 2009. Prevalensi Hipokalemia Pada Pasien Dengan Kegawatan Neurologi Di Ruang Rawat Neurologi RSUPN Cipto Mangunkusumo. Neurona (Majalah Kedokteran Neuro Sains Perhimpunan Dokter Spesialis Saraf Indonesia) 26(2). 5. Aras, Sriwaty. 2007. Prevalensi dan Distribusi Gangguan Elektrolit Pada Lanjut Usia di Bangsal Penyakit Dalam RSUP Dr. Kariadi Semarang: 7. 6. Ardyanto, Tonang Dwi, and Tahono Tahono. 2018. Kadar Serum Kreatinin dan Kalium Pasien dengan dan Tanpa Diabetes Jenis (Tipe) II. 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Archives of Internal Medicine 160(16): 2429–36. 12. DeCarolis, Douglas D, Grace Miran Kim, Thomas S Rector, and Areef Ishani. 2016. Comparative Dose Response Using the Intravenous versus Enteral Route of Administration for Potassium Replenishment. Intensive & critical care nursing 36: 17–23. 13. Duarte, Julio D, and Rhonda M Cooper-DeHoff. 2010. Mechanisms for Blood Pressure Lowering and Metabolic Effects of Thiazide and Thiazide-like Diuretics. Expert review of cardiovascular therapy 8(6): 793–802. 14. Elliott, Taiwona L, and Michael Braun. 2017. Electrolytes: Potassium Disorders. FP essentials 459: 21–28. 15. Gama, Helena. 2007. Drug Utilization Studies. Arq Med: 22. 16. Gan, Huo-Ye et al. 2019. Association between Hypokalemia and Small Bowel Capsule Endoscopy Completion Rates in Patients in South China: A Prospective Single-Center Study. Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association 25(1): 40. 17. 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Koreksi Hipokalemia Dengan KCL Pada Pasien-Pasien Di ICU Rumah Sakit Dr. Hasan Sadikin Bandung Januari–Februari 2014. 33 No.2: 88. 24. Hinderling, Peter H. 2016. The Pharmacokinetics of Potassium in Humans Is Unusual. The Journal of Clinical Pharmacology 56(10): 1212– 20. 25. Iryanto, Alfian. 2017. Studi Penggunaan Kombinasi Diuretik Pada Pasien Gagal Jantung (Penelitian Dilakukan di Instalasi Rawat Inap RS Umum Daerah Sidoarjo): 55. 26. Johnston, Corry T et al. 2017. Evaluation of an Intravenous Potassium Dosing Algorithm for Hypokalemic Critically Ill Patients. JPEN. Journal of parenteral and enteral nutrition 41(5): 796–804. 27. Joyce L. Kee, Evelyn R. Hayes. 1996. Farmakologi : Pendekatan Proses Keperawatan. Jakarta : Penerbit Buku Kedokteran EGC 140-145. 28. Kardalas, Efstratios et al. 2018. Hypokalemia: A Clinical Update. Endocrine connections 7(4): R135–46. 29. Lee, Jay Wook. 2010. Fluid and Electrolyte Disturbances in Critically Ill Patients. Electrolytes & Blood Pressure 8(2): 72–81. 30. Lewis, J L. 2009. Disorders of Potassium Concentration. The Merck Manual. Merck & Co., Inc., Whitehouse Station, NJ: 2. 31. Li, Lingyun et al. 2016. Mechanism of Action and Pharmacology of Patiromer, a Nonabsorbed Cross-Linked Polymer That Lowers Serum Potassium Concentration in Patients with Hyperkalemia. Journal of cardiovascular pharmacology and therapeutics 21(5): 456–65. 32. Luckey, Andrew E, and Cyrus J Parsa. 2003. Fluid and Electrolytes in the Aged. Archives of surgery 138(10): 1055–60. 33. Makkiyah, Feda Anisah, Denny Evander Pasamboan, and Agneta Irmarahayu. 2020. Pengaruh Gangguan Elektrolit Terhadap Prognosis Pasien Traumatic Brain Injury. Jurnal Kesehatan 11(2): 127–31. 34. Mariyono, Harbanu H, and Anwar Santoso. 2007. Gagal Jantung. J Peny Dalam 8(3): 85–94. 35. Marti, Grischa et al. 2014. Etiology and Symptoms of Severe Hypokalemia in Emergency Department Patients. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 21(1): 46–51. 36. McMahon, Robert S, and Khalid Bashir. 2020. Potassium Chloride. In Treasure Island (FL): 5. 37. Moon, Changsuk et al. 2015. Drug-Induced Secretory Diarrhea: A Role for CFTR. Pharmacological research 102: 107–12. 38. Mount, David B. 2012. Fluid and Electrolyte Disturbances. Harrison’s principles of internal medicine, 18th edn. New York: McGraw-Hill: 341–59. 39. Nathania, Maggie. 2019. Hipokalemia–Diagnosis Dan Tatalaksana. CDK- 273/vol2: 103-107. 40. NHS. 2019. Management of Hypokalaemia Clinical Guideline. (August). V2.0: 1-13. 41. Ofek, Fanny et al. 2016. Introducing a Change in Hospital Policy Using FMEA Methodology as a Tool to Reduce Patient Hazards. Israel journal of health policy research 5: 30. 42. Padmasiri, Dr Lushantha et al. 2017. Guidelines for the Management of Dyslipidaemia. 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Indonesian Journal of Clinical Pathology and Medical Laboratory 15(3): 95– 97. 53. Syarfina, Fairuza. 2017. Pola Penggunaan Insulin Pada Pasien Diabetes Melitus Tipe 2 (Studi Dilaksanakan Di Instalasi Rawat Inap Rumah Sakit Universitas Airlangga Surabaya). Perpustakaan Universitas Airlangga: 65. 54. Tests, BPAC Best. 2011. A Primary Care Approach to Sodium and Potassium Imbalance. September/imbalance. aspx: 3-13. 55. Tjay, Tan Hoan, and Kirana Rahardja. 2007. Obat-Obat Penting: Khasiat, Penggunaan Dan Efek-Efek Sampingnya. Elex Media Komputindo: 547. 56. Unwin, Robert J, Friedrich C Luft, and David G Shirley. 2011. Pathophysiology and Management of Hypokalemia: A Clinical Perspective. Nature Reviews Nephrology 7(2): 75. 57. Valeur, Jørgen, and Joar Julsrud. 2013. Vomiting: A Physiological Response to Acidosis? Scandinavian journal of gastroenterology 48(9): 1103–4. 58. Wanat, M A, and J T Swan. 2013. Johnson TJ. Critical Care Pharmacotherapeutics. Burlington, MA: Jones and Bartlett Learning: 125. 59. Widodo, Djoko et al. 2006. The Prevalence of Hypokalemia in Hospitalized Patients with Infectious Diseases Problem at Cipto Mangunkusumo Hospital, Jakarta. Acta Med Indones 38(4): 202–5. 60. Wulandari, Tri. Gambaran Penggunaan Obat Pada Pasien Gagal Jantung Kongestif Rawat Inap di Rumah Sakit Sultan Syarif Mohamad Alkadrie Pontianak. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN 3(1). 61. You, Lili et al. 2017. A Retrospective Analysis of Postoperative Hypokalemia in Pituitary Adenomas after Transsphenoidal Surgery. PeerJ 5: e3337. 62. Yusri, Yunisa Friscia, Lia Amalia, and Ida Lisni. 2019. Studi Penggunaan Obat Untuk Menangani Gangguan Natrium Dan Kalium Pasien Penyakit Ginjal Terminal Di RS Muhammadiyah Bandung. Jurnal Sains Farmasi & Klinis 5(3): 233–42. Studi Penggunaan Suplemen Kalium Pada Pasien Hipokalemia Yang Mendapat Terapi Kalium Intravena Septiana Syahrani NIM051611133177 Hypokalemia, potassium disorders, intravenous potassium Hypokalemia is a state of blood potassium concentration below 3,5 mEq/L which is caused by a decrease in the total body potassium amount or a disturbance in the movement of potassium ions into cells. This study aims to determine the pattern of use of potassium therapy in hypokalemia patients receiving intravenous potassium therapy. The data obtained from previous studies related to the use of intravenous potassium therapy for hypokalemia patients at Hospital X for the period November 2015-September 2017. 41 patients who met the inclusion criteria were classified into three category hypokalemia, mild hypokalemia (4,9%), moderate hypokalemia (61%) and severe hypokalemia (34,1%). Types of intravenous potassium were potassium infusion A (23,8%), potassium infusion B (45,3%), potassium infusion C (7,1%) and potassium infusion D (23,8%). The rate of potassium infusion given was potassium infusion A 1,7 mEq/hour, potassium infusion B 4,2 mEq/hour, potassium infusion C 1,2 mEq/hour and potassium infusion D 2,5 mEq/hour. The success of hypokalemia correction was achieved in 46,3% (19 patients) and the unsuccessful correction was achieved in 53,7% (22 patients). Factors that affect the increase in potassium concentration are the therapeutic dose and the rate of potassium infusion, while the type of intravenous potassium supplementation has no effect on the increase in potassium. It can be concluded that the use of hypokalemia therapy is in accordance with the clinical condition of the patient and the guidelines for the management of hypokalemia therapy.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKC KK FF.PA.86-21 Sya s | |||||||||
| Uncontrolled Keywords: | Hypokalemia, potassium disorders, intravenous potassium | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Pendidikan Apoteker | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 11 Nov 2021 04:24 | |||||||||
| Last Modified: | 11 Nov 2021 04:24 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/112493 | |||||||||
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