José Villar, - and Shabina Ariff, - and Robert B. Gunier, - and Ramachandran Thiruvengadam, - and Stephen Rauch, - and Alexey Kholin, - and Paola Roggero, - and Federico Prefumo, - and Marynéa Silva do Vale, - and Jorge Arturo Cardona-Perez, - and Nerea Maiz, - and Irene Cetin, - and Valeria Savasi, - and Philippe Deruelle, - and Sarah Rae Easter, - and Joanna Sichitiu, - and Constanza P. Soto Conti, - and Ernawati, - and Mohak Mhatre, - and Jagjit Singh Teji, - and Becky Liu, - and Carola Capelli, - and Manuela Oberto, - and Laura Salazar, - and Michael G. Gravett, - and Paolo Ivo Cavoretto, - and Vincent Bizor Nachinab, - and Hadiza Galadanci, - and Daniel Oros, - and Adejumoke Idowu Ayede, - and Loïc Sentilhes, - and Babagana Bako, - and Mónica Savorani, - and Hellas Cena, - and Perla K. García-May, - and Saturday Etuk, - and Roberto Casale, - and Sherief Abd-Elsalam, - and Satoru Ikenoue, - and Muhammad Baffah Aminu, - and Carmen Vecciarelli, - and Eduardo A. Duro, - and Mustapha Ado Usman, - and Yetunde John-Akinola, - and Ricardo Nieto, - and Enrico Ferrazi, - and Zulfiqar, - (2021) Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection The INTERCOVID Multinational Cohort Study. JAMA Pediatrics, 175 (8). pp. 817-826. ISSN 2168-6203

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Abstract

Importance Detailed information about the association of COVID-19 with outcomes in pregnant individuals compared with not-infected pregnant individuals is much needed. Objective To evaluate the risks associated with COVID-19 in pregnancy on maternal and neonatal outcomes compared with not-infected, concomitant pregnant individuals. Design, Setting, and Participants In this cohort study that took place from March to October 2020, involving 43 institutions in 18 countries, 2 unmatched, consecutive, not-infected women were concomitantly enrolled immediately after each infected woman was identified, at any stage of pregnancy or delivery, and at the same level of care to minimize bias. Women and neonates were followed up until hospital discharge. Exposures COVID-19 in pregnancy determined by laboratory confirmation of COVID-19 and/or radiological pulmonary findings or 2 or more predefined COVID-19 symptoms. Main Outcomes and Measures The primary outcome measures were indices of (maternal and severe neonatal/perinatal) morbidity and mortality; the individual components of these indices were secondary outcomes. Models for these outcomes were adjusted for country, month entering study, maternal age, and history of morbidity. Results A total of 706 pregnant women with COVID-19 diagnosis and 1424 pregnant women without COVID-19 diagnosis were enrolled, all with broadly similar demographic characteristics (mean [SD] age, 30.2 [6.1] years). Overweight early in pregnancy occurred in 323 women (48.6%) with COVID-19 diagnosis and 554 women (40.2%) without. Women with COVID-19 diagnosis were at higher risk for preeclampsia/eclampsia (relative risk [RR], 1.76; 95% CI, 1.27-2.43), severe infections (RR, 3.38; 95% CI, 1.63-7.01), intensive care unit admission (RR, 5.04; 95% CI, 3.13-8.10), maternal mortality (RR, 22.3; 95% CI, 2.88-172), preterm birth (RR, 1.59; 95% CI, 1.30-1.94), medically indicated preterm birth (RR, 1.97; 95% CI, 1.56-2.51), severe neonatal morbidity index (RR, 2.66; 95% CI, 1.69-4.18), and severe perinatal morbidity and mortality index (RR, 2.14; 95% CI, 1.66-2.75). Fever and shortness of breath for any duration was associated with increased risk of severe maternal complications (RR, 2.56; 95% CI, 1.92-3.40) and neonatal complications (RR, 4.97; 95% CI, 2.11-11.69). Asymptomatic women with COVID-19 diagnosis remained at higher risk only for maternal morbidity (RR, 1.24; 95% CI, 1.00-1.54) and preeclampsia (RR, 1.63; 95% CI, 1.01-2.63). Among women who tested positive (98.1% by real-time polymerase chain reaction), 54 (13%) of their neonates tested positive. Cesarean delivery (RR, 2.15; 95% CI, 1.18-3.91) but not breastfeeding (RR, 1.10; 95% CI, 0.66-1.85) was associated with increased risk for neonatal test positivity. Conclusions and Relevance In this multinational cohort study, COVID-19 in pregnancy was associated with consistent and substantial increases in severe maternal morbidity and mortality and neonatal complications when pregnant women with and without COVID-19 diagnosis were compared. The findings should alert pregnant individuals and clinicians to implement strictly all the recommended COVID-19 preventive measures.

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