Irma Sarita Rahmawati, - and Soetjipto, - and Annis Catur Adi, - and Aulanni’am, - (2017) RENIN ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS) PROFILE OF ADMINISTRATION OF ETHANOL EXTRACT OF PURPLE SWEET POTATO VAR. AYAMURASAKI IN DOCA-SALT HYPERTENSIVE RATS. Journal of Applied Food Technology, 4 (2). pp. 35-38. ISSN 2614-7076

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Abstract

There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanine found in purple sweet potato generates bioactive compound with antihypertensive and anti-ACE activities in RAA system. The present study sought to investigate anti-ACE activities in RAA system of extract ethanol of purple sweet potato (EP) in deoxycorticosterone acetate (DOCA–salt)–induced hypertensive rats (Rattus norvegicus). The rats were orally administrated a 95% ethanol extract of purple sweet potato (var. ayamurasaki) (EP) in a daily dose of 200 and 400 mg/kg body weight also chlorogenic acid (CA) of 700 mg/kg bw for 4 weeks. Activity of renin, ACE, and Ang II concentration were assessed. Inhibiting activity of renin, ACE, and decreasing Ang II concentration after treatment was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; (P<0.05). This is the first report that demonstrates the lowering of blood pressure and anti-ACE in RAA-system effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA–salt model of hypertension.

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