Eduardus Bimo Aksono Herupradoto, - and D. Adriaty, - and R. Wahyuni, - and Iswahyudi, - and I. Agusni, - and S. Izumi, - and Nasronudin, - and M. Lusida, - and T. Koesbardiati, - (2013) Diversity of Mycobacterium leprae On The Basis of Repetitive Sequences of TTC From Ancient Bones Found in Bali and East Nusa Tenggara, East Indonesia. World Health Organization, Brussel - Belgia.

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Abstract

Introduction : Excavalions of the genetic material of pathogenic organisms in the ancient bones provide important informations for the study of certain infevtious diseases in ancient populations. In addition, the identification of bacterial DNA provides direct evidence and the frequency of occurrence of infectious disease in ancient populations and may provide information about the evolution of microorganisms and related disease. Several recent reports have succeeded in isolating several Mycobacterium by using PCR technique, because the PCR technique, although very small amount of DNA in ancient biomaterials such as bone or soft tissue but can be identified. This new approach not only of knowledge related to the evolution of different strains of Mycobacterium, but may also provide correlative data on the influence of environment on the development of Mycobacterium and biodiversity. However until now has never reported any Mycobacterium especially Mycobacterium leprae was found in a ancient bones from Indonesia, so too has not been widely report throughout the world of M. leprae from ancient bones found on the old 2990 + / - 160 BP. The purpose of this study was performed diversity analysis of M. leprae on the basis of repetitive sequences of TTC from ancient bones in Bali and East Nusa Tenggara, East Tenggara.

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