Tito Sumarwoto, - and Heri Suroto, - and Dwikora Novembri Utomo, - and Romaniyanto, - and Damayanti Tinduh, - and Hari Basuki Notobroto, - and Cita Rosita Sigit Prakoeswa, - and Fedik Abdul Rantam, - and Sholahuddin Rhatomy, - (2021) Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration. Annals of Medicine and Surgery, 67. pp. 1-10. ISSN 2049-0801

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Abstract

The use of stem cells is a breakthrough in medical biotechnology which brings regenerative therapy into a new era. Over the past several decades, stem cells had been widely used as regenerative therapy and Mesenchymal Stem Cells (MSCs) had emerged as a promising therapeutic option. Currently stem cells are effective therapeutic agents againts several diseases due to their tissue protective and repair mechanisms. This therapeutic effect is largely due to the biomolecular properties including secretomes. Injury to peripheral nerves has significant health and economic consequences, and no surgical procedure can completely restore sensory and motor function. Stem cell therapy in peripheral nerve injury is an important future intervention to achieve the best clinical outcome improvement. Adipose mesenchymal stem cells (AdMSCs) are multipotent mesenchymal stem cells which are similar to bone marrow-derived mesenchymal stem cells (BM-MSCs). The following review aims to provide an overview of the use of AdMSCs and their secretomes in regenerating peripheral nerves.

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