Low Carbohydrate High Protein Diet Reduces Levels of Tumour Necrosis Factor-α (TNF-α) in Rats (Rattus norvegicus)

Hany Aryani, - and Budi Santoso, - and Bambang Purwanto, - (2020) Low Carbohydrate High Protein Diet Reduces Levels of Tumour Necrosis Factor-α (TNF-α) in Rats (Rattus norvegicus). Indian Journal of Public Health Research & Development, 14 (4). pp. 2923-2928. ISSN 0973-9122

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Official URL: https://medicopublication.com/index.php/ijfmt/arti...


The purpose of this study is to explain the effect of a low-carbohydrate-high-protein (LCHP) diet on reducing TNF-α levels. The study was carried out with true experimental post-test only control design, using 3-month-old females rats (Rattus norvegicus) with a bodyweight of 200-300 g, which were divided into three groups: Negative control (K-) (rats without treatment were fed with broiler standard feed), Positive control (K+) (PCOS-IR model rats were fed broiler standard feed), and Treatment (P) (PCOS-IR model mice were fed with LCHP diet). Serum taken from the rats’ heart on day 49 was examined for TNF-α levels using Bioassay Germany ELISA kit. Statistical analysis was carried out using ANOVA and Post Hoc tests. ANOVA analysis of TNF-α resulted in a p value of 0.0017, indicating significant difference of TNF-? levels when LCHP diet was applied, followed by Post Hoc test found that the TNF-? level of the treatment group (p = 0.006) is lower than the positive control group (p = 0.038). One of the roles of a low-carbohydrate diet in the pathogenesis of PCOS-IR is to provide an inflammatory repair effect by increasing insulin sensitivity, improving insulin levels, and stimulating an increase in steroidogenesis synthesis. Increased breakdown of fatty acids is inhibited, so that it does not cause a build-up of fatty acids and does not induce an increase in proinflammatory cytokines against gonadotropins, increasing FSH secretion and effecting follicular development.

Item Type: Article
Uncontrolled Keywords: low-carbohydrate-high-protein diet (LCHP), polycystic ovary syndrome, and TNF-α levels
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Faal
Budi Santoso, -NIDN0017026307
Bambang Purwanto, -NIDN0028088001
Depositing User: arys fk
Date Deposited: 10 Feb 2022 01:41
Last Modified: 10 Feb 2022 01:41
URI: http://repository.unair.ac.id/id/eprint/113468
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