A. N. Kristanti, .- and H. Suwito, .- and N.S. Aminah, .- and K.U. Haq, .- and H. D. Hardiyanti, .- and H. Anggraeni, .- and N. Faiza, .- and R.S. Anto, .- and S. Muharromah, .- (2020) SYNTHESIS OF SOME CHALCONE DERIVATIVES, IN VITRO AND IN SILICO TOXICITY EVALUATION. Rasayan Journal of Chemistry, 13 (1). pp. 654-662. ISSN 0974-1496 | e-ISSN: 0976-0083

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Abstract

Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the best method. The objevtives of this study were to synthesize some chalcone derivatives using conventional ClaisenSchmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´- hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.

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