Glut-1 Is A Promising Target For Atp Deplesion On Diabetic Energy Deficiency Syndrome Repository

Glut-1 Is A Promising Target For Atp Deplesion On Diabetic Energy Deficiency Syndrome

Bambang Purwanto, - and Harjanto, - and Elyana Asnar, - (2017) Glut-1 Is A Promising Target For Atp Deplesion On Diabetic Energy Deficiency Syndrome. Folia Medica Indonesiana, 53 (3). pp. 177-179. ISSN 2599256X

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Official URL: https://e-journal.unair.ac.id/FMI/article/view/644...

Abstract

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.

Item Type:

Article

Uncontrolled Keywords:

Diabetes, glucose transporter, energy deficiency, eccentric, streptozotocin

Subjects:

R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Faal

Creators: