Anisa Maharani and Teguh H. Sucipto and Harsasi Setyawati and Yovilianda M. Untoro and Novia F. Sholihah and Siti Churrotin and Ilham H. Amarullah and Puspa Wardhani and Aryati and Soegeng Soegijanto (2020) In Vitro Antiviral Activity of Morin Compound against Dengue Virus Type 1 in Vero Cells. Systematic Reviews in Pharmacy, 11 (9). pp. 830-833. ISSN 09758453

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Abstract

Dengue Haemorrhagic Fever (DHF) is an irresistible ailment brought about by dengue infection. Recently, the medicine for dengue fever cannot be disseminated in various countries because of the price was high. One characteristic of a person infected with the virus was thrombocyte decreasing. In previous research it was known that guava can increase the number of thrombocyte patients of dengue fever. Guava was trusted can increase the number of thrombocyte because it contains a group of tannin and flavonoids as anti-bacterial. Some flavonoids in guava include morin, quercetin, and guajavarin. Objective: Purpose in this study, was to decide the impact of morin compound to the replication of dengue infection. Methods: This study used to test the inhibition of the virus is by Viral ToxGlo assay to know the value of 50% inhibition of morin compound on dengue virus replication (IC50) and cytotoxicity to determine the toxicity level of the morin compound against body cell (CC50). Results: This study of IC50 morin for dengue compounds is 9.42 µg/ml and the result of CC50 in Vero cell is 12.46 µg/ml. Conclusion: In summary, there was an investigation show that morin compound have harmful properties in the body.

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