Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia

Aryati, - and Billy J. Wrahatnala, - and Benediktus Yohan, - and May Fanny Tanzilia, - and Faradila K.N. Hakim., - and Eka Putri Sunari, - and Nelly Zuroidah, - and Puspa Wardhani, - and Marsha S. Santoso, - and Dominicus Husada, - and Ali Rohman, - and Siti Nadia Tarmizi, - and Justus T. O. Sievers, - and R. Tedjo Sasmono, - (2020) Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia. Viruses 2020, 12 (9). pp. 1-20. ISSN 19994915

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Outbreaks of dengue virus (DENV) in Indonesia have been mainly caused by the DENV serotype-1; -2; or -3. The DENV-4 was the least-reported serotype in Indonesia during the last five decades. We recently conducted a molecular epidemiology study of dengue in the Jember regency, East Java province, Indonesia. Dengue is endemic in the region and outbreaks occur annually. We investigated the clinical characteristics and etiology of dengue-like febrile illness in this regency to understand the disease dynamics. A total of 191 patients with clinical symptoms similar to dengue were recruited during an 11-month study in 2019–2020. Children accounted for the majority of cases and dengue burden was estimated in 41.4% of the cases based on NS1 antigen, viral RNA, and IgG/IgM antibody detection with the majority (73.4%) being primary infections. Secondary infection was significantly associated with a higher risk of severe dengue manifestation. All four DENV serotypes were detected in Jember. Strikingly, we observed the predominance of DENV-4, followed by DENV-3, DENV-1, and DENV-2. Genotype determination using Envelope gene sequence revealed the classification into Genotype I, Cosmopolitan Genotype, Genotype I, and Genotype II for DENV-1, -2, -3, and -4, respectively. The predominance of DENV-4 in Jember may be associated with a new wave of DENV infections and spread in a non-immune population lacking a herd-immunity to this particular serotype.

Item Type: Article
Uncontrolled Keywords: dengue, molecular epidemiology, serotype, Java, Indonesia
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: 01. Fakultas Kedokteran > Patologi Klinik
Aryati, -NIDN0015086304
Billy J. Wrahatnala, -UNSPECIFIED
Benediktus Yohan, -UNSPECIFIED
May Fanny Tanzilia, -UNSPECIFIED
Faradila K.N. Hakim., -UNSPECIFIED
Eka Putri Sunari, -UNSPECIFIED
Nelly Zuroidah, -UNSPECIFIED
Puspa Wardhani, -NIDN0025027506
Marsha S. Santoso, -UNSPECIFIED
Dominicus Husada, -NIDN8800010016
Siti Nadia Tarmizi, -UNSPECIFIED
Justus T. O. Sievers, -UNSPECIFIED
R. Tedjo Sasmono, -UNSPECIFIED
Depositing User: arys fk
Date Deposited: 23 Feb 2022 04:31
Last Modified: 19 May 2022 07:44
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