Fatmawati, .- and Hengki Tasman, .- (2015) An optimal control strategy to reduce the spread of malaria resistance. Mathematical Biosciences, 262 (2015). pp. 73-79. ISSN 0025-5564
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Abstract
This paper presents a mathematical model of malaria transmission considering the resistance of malaria parasites to the anti-malarial drugs. The model also incorporates mass treatment and insecticide as control strategies. We consider the sensitive and resistant strains of malaria parasites in human and mosquito populations. First, we investigated the existence and stability of equilibria of the model without control based on two basic reproduction ratios corresponding to the strains. Then, the Pontryagins Maximum Principle is applied to derive the necessary conditions for optimal control. Simulation results show the effectiveness of the optimal control to reduce the number of infected hosts and vectors.
| Item Type: | Article | ||||||
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| Uncontrolled Keywords: | Mathematical model; Optimal control; Malaria resistance; Basic reproduction ratio | ||||||
| Subjects: | Q Science Q Science > QA Mathematics Q Science > QA Mathematics > QA370-387 Differential Equations |
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| Divisions: | 08. Fakultas Sains dan Teknologi > Matematika | ||||||
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| Depositing User: | Mr Vega Andi Budiman | ||||||
| Date Deposited: | 22 Mar 2022 14:50 | ||||||
| Last Modified: | 22 Mar 2022 14:50 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/114274 | ||||||
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