Andrianto, - and Ronaldi Rizkiawan, - and Primasitha Maharany Harsoyo, - and Syafira Yasmine, - (2021) COVID-19 AND ENDOTHELIAL DYSFUNCTION: BIOMARKERS AND POTENTIAL DRUG MECHANISMS. Indonesian Journal of Tropical and Infectious Disease, 9 (3). pp. 109-119. ISSN 2356-0991

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Since the fi rst report of pneumonia outbreak in Wuhan by the end of 2019, Coronavirus Disease 2019 (COVID-19) has become a global pandemic; causing millions of deaths globally and aff ecting the rest of worldwide population. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which enters hosts by inhabiting Angiotensin-Converting Enzyme-2 (ACE-2) receptors expressed in the endothelium layer of not only the respiratory tracts, but also various organs in the body. COVID-19 has been reported to trigger multiple cardiovascular manifestations. Since endothelial dysfunction plays an important role in cardiovascular events and the endothelium is heavily involved in COVID-19 pathophysiology, it is important to investigate their associations and previously established drug potencies to improve endothelial functions as possible treatment options for COVID-19. In this review, we summarize endothelial dysfunction biomarkers involved in COVID-19 and drugs that have shown potential endothelial protective properties to better understand the incidence of endothelial dysfunction in COVID-19 and its future treatment. We searched in PubMed, Wiley Online Library, EBSCO, ScienceDirect databases for literatures containing following keywords: “Endothelial dysfunction”, “COVID-19”, and “biomarkers”. Eligible publications were then assessed and studied to comprise our literature review. A total of 96 studies matched our criteria and provided scientifi c evidences for our review. Materials were then compiled into a review summarizing endothelial biomarkers involved in COVID-19 and potentially repurposed drugs targeting endothelium for COVID-19.Various endothelial dysfunction biomarkers were found to be elevated in COVID19 and is found to be related to its severity, such as adhesion molecules, selectins, PAI-1, and von Willebrand Factors. Multiple drugs targeting the endothelium are also potential and some are under investigation for COVID-19.

Item Type: Article
Uncontrolled Keywords: COVID-19, endothelial dysfunction, SARS-COV-2, biomarkers
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC666-701 Diseases of the circulatory (Cardiovascular) system
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Jantung
Andrianto, -NIDN8877700016
Ronaldi Rizkiawan, -UNSPECIFIED
Primasitha Maharany Harsoyo, -UNSPECIFIED
Syafira Yasmine, -UNSPECIFIED
Depositing User: arys fk
Date Deposited: 29 Mar 2022 04:42
Last Modified: 29 Mar 2022 04:42
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