Muhammad Luthfi, - and Aqsa Sjuhada Oki, - and Retno Indrawati, - and Muhaimin Rifai, - and Yoes Prijatna Dachlan, - and Fathilah Abdul Razak, - (2020) CD89/CD35 Expression Ratio in Salivary Neutrophil as an Early Detection Marker for Severe Early Childhood Caries. European Journal of Dentistry, 14 (3). pp. 386-392. ISSN 13057464

	Text (ARTIKEL) CD89 CD35 Expression Ratio in Salivary Neutrophil as an.pdf Download (1MB)
	Text (SIMILARITY) 1. CD89CD35 Expression Ratio in Salivary Neutrophil as an Early Detection Marker for Severe Early Childhood Caries (1).pdf Download (2MB)
	Text (VALIDASI) 1. Dr.Luthfi ( CD89 CD 35 Expression...).pdf Download (958kB)
	Text (PENILAIAN) 1. Kualitas Karil dan Kesesuaian Bidang Ilmu.pdf Download (519kB)

Abstract

Objectives To analyze CD35/CD89 expression ratio on the surface of neutrophils as an early detection marker for S-ECC. Materials and Methods Saliva was collected from 4- to 6-year-old kindergarten students. Salivary neutrophils were obtained by instructing the subjects to rinse their mouth with 1 mL of sterile 1.5% NaCl for 30 seconds before expectorating it into a sterile glass. The expression of CFSE+CD35+ and CFSE+CD89+was measured and analyzed using flow cytometry. Results The expression of CFSE+CD89+ in the caries-free group (2.46 ± 0.39) was significantly lower than that in the S-ECC group (3.41 ± 1.11), with a p-value of 0.0001, while the expression of CFSE+CD35+ in the caries-free group was (2.35 ± 0.56) compared with (1.54 ± 0.35) (p = 0.0001) in the S-ECC group. Conclusions The expression ratio of CFSE+CD89+ and CFSE+CD35+constitutes a marker for S-ECC.

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