David Buntoro Kamadjaja, - and Handhito Satriyo, - and Aris Setyawan, - and Yeni Dian Lesmaya, - and Jefry Wahyudi Safril, - and Ni Putu Mira Sumarta, - and Andra Rizqiawan, - and Coen Pramono Danudiningrat, - and Ta To Tran, - (2021) Analyses of Bone Regeneration Capacity of Freeze-Dried Bovine Bone and Combined Deproteinized–Demineralized Bovine Bone Particles in Mandibular Defects: The Potential Application of Biological Forms of Bovine-Bone Filler. European Journal of Dentistry, 2021. pp. 1-11. ISSN 1305-7456

	Text (ARTIKEL) 22 Analyses of Bone Regeneration.pdf Download (11MB)
	Text (TURNITIN) 22_Analyses of Bone Regeneration_turnitin.pdf Download (6MB)
	Text (VALIDASI) 22 Analyses of Bone Regeneration-validasi.pdf Download (3MB)
	Text (VALIDASI 2) Artikel 14 Andra Rizqiawan.pdf Download (3MB)
	Text (KARIL) 17.Analyses.pdf Download (1MB)
	Text (KARIL 1) 17.pdf Download (1MB)
	Text (TURNITIN 2) Analyses of Bone Regeneration Capacity of FreezeDried Bovine Bone and Combined Deproteinized– Demineralized Bovine Bone Particles in Mandibular Defects_ The Potential Application of Biological Forms o_2.pdf Download (6MB)

Abstract

Objective This study aimed to evaluate bone regeneration capacity of FDBX granules compared to composite DBBM/DFDBX granules for filling of bone defect in rabbit mandible. Material and Methods Critical size defects were created in 45 rabbits’ mandible. The defect in the control group is left untreated, while in other groups the defects were filled with FDBX granules and composite DBBM/DFDBX granules, respectively. Specimens were collected at 2, 4, and 8 weeks for histology and immunohistochemical analyses. Significant difference is set at p-value<0.05. Results The osteoblast-osteoclast quantification, osteoblast expression of Runx2, alkaline phosphatase, collagen-I, and osteocalcin, and osteoclast expression of receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) in FDBX groups were statistically comparable (p>0.05) with the composite group, while OPG/RANKL ratio, bone healing scores, and trabecular area were significantly higher (p<0.05) in the composite compared to FDBX group. Conclusion Composite DBBM/DFDBX granules, within the limitation of this study, has better bone forming capacity than FDBX granules for filling of bone defects in the mandible.

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