Latief Mooduto and Dian Agustin Wahjuningrum and Ari Subijanto and Mohammed Rafiq bin Dato'Abdul Kadir and Ardiansyah Syahrom (2018) Optimalization The Potency Of Anti-Osteoporosis Of Apis Dorsata Honey For The New Natural Compound Preparation To Prevent Osteoporosis. Laporan Penelitian. Universitas Airlangga, Surabaya. (Unpublished)

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Abstract

Osteoporosis (OP), defined as low bone mass leading to increased fracture risk, is a major health problem. In Indonesia one from four female had OP risk (50-S0ys). The costs of osteoporotic fracture-related morbidity and mortality will burden the Indonesian healthcare system. Treatment of high-risk patients with antiresorptive medications such as bisphosphonates. For postmenopausalosteoporosis, the main treatment is estrogen replacement therapy (ERT). Despite its effectiveness, ERT, however, can cause many adverse effects. Adequate nutrition plays a major role in the prevention and treatment of osteoporosis; the micronutrients of greatest importance arc calcium and vitamin D. Calcium has been shown to have beneficial effects on bone mass at all ages, although the results are not always consistent cause depend on the capacity of Calcium absorption. The absorption of Calcium will increase as the amount of honey taken was upped. Indonesia is the top second biodiversity in the world which has 7 species of beef while. Honey is one of their product. Honeyas alternative treatment that is rich in antioxidant and also an anti-inflammatory effect can be given to replace the conventional ERT. Apis Dorsata honey is one of the best options available as it contains antioxidant as well as exerting anti inflammatory effect which can act as a free radical scavenger, reducing the oxidative stress level as well as inhibit ing proinflammatory cytokine. This will result in surv ival of ostcoblasts, reduced osteoclastogenic activity, and consequently, reduce bone loss. Hence, Apis Dorsatahoney can be used as an alternative treatment of postmenopausal osteoporosis with minimal side effects. The aim of this study are to find the new natural compounds for up of absorption Calcium response, to determine the suppressive mechanism of OP by new natural compound and to confirm the effect of new natural Honey compounds in animal experiment. In three years, the research project wi ll be conducted by two institutions, Faculty of Dental Medicine Universitas Airlangga-Indonesia and Faculty of Biosciences & Medical Engineering Universiti Teknologi Malaysia (UTM)-Johor Bahru, Malaysia. At the first year we wi ll focus on microstructure of bone effect by Apis Dorsata Honey. Total volume, bone volume, bone volume density, trabecular thickness, trabecular spacing, trabecular number, bone surface, cortical thickness, bone mineral content and bone mineral density are determined by J-ICT and FESEM analysis are used to evaluate the microarchitecture and porosity of bone tissue influence by Apis Dorsata honey. Second, the experiment will focus on biomolecular and host respon by survival of osteoblasts, reduced osteoclastogenic activity. and consequently, reduce bone loss to evaluate the bone tissue activity. On the third year this project will be fini shed by optimizing preparat of Apis Dorsata Honey preparation as Drug patent also stability assesment material.Partner of this project had high experience on bone research and freque nly on publishing with Q1, Q2, ISI lndex (113 paper) Scopus Index ( 163 paper) also owner some of invention (32 patents granted; 28 patend pending); copyrights (36); Impact Factor (229.854); hIndex( IS); books (6). That's why by this collaboration research, we expect the new natural compounds will be discovered. Furthermore, we confident submit the result of this project for international publication every years. The target joumal is Journal of Material Science. The expected result will be gained as soon as possible and the new preventive medicine for OP will be created for human being.

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