Imran Yahya, - and Marzuki S,, - and Nur Haryono, - and Hadi Purnomo, - and Loethfi Oesman, - (1982) Measurement Of Hdl-Cholesterol Concentration In Acute Myocardial Infarction On Men 35 Years And Over. Laporan Penelitian. FAKULTAS KEDOKTERAN. (Unpublished)

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Abstract

Measurement Of Hdl-C (High Density Lipoprotein Cholesterol) Concentration Had Been Undertaken For 30 Acute Myocardial Infarction And 31 Control Subjects. The Concentration Of Bar-Gct:Kiitainthdl-C Was Measured By The 'Method Due To Samaille, Which Is Modified By Lopes-Virella Et Al; Choles Terol Concentration Was Measured By Enzymatic Method Due To Roschlf Gruber, Using Boehringer-Manheim Reagent Kit No. 400971 And No. 231347. It Had Been Found That The Concentration Of Hdl-C Was Higher In Acute Myocardial Infarction (44,45 Mg/D1) Than Control (34,55 Mg/D1) And The Difference Was Significant ( P<0,02 ). Other Measurements Were Performe&Total Cholesterol Was Lower In Acute Myocardial Infarction Than Control Subjectsp> 0,05 ); Triglyceride Was Also Lower Than The Control Subjects And The Difference Was Signifie Cant Risk factors for cardiovascular disease have been discussed in the medical literature for many years. Their significant in myocardial infarction has been intensively investigated and graded in numerous studies. The factors are o hypercholesterolemia, cigaret smoking, hypertension, overweight, lack of exercise, diabetes mellitus, gout and hyperuricaemia, polycythemia It must nowadays be regarded as definite that risk factors accelQrdk, the development of arteriosclerotic proceses. Not only the lipids, but also their transport-forms, the lipoproteins, are of significance for the atherogenic potential. Particularly feared because of their high atherogenic potential are the low density lipoproteins (LDL), which transport the larger part of the cholesterol in blood. However, the lipoproteins of the very low density (VLDL) , which mainly transport triglycerides, also facilitate the development of atherosclerotic changes. Risk factors represent, however, only a part of the problem. (1,4,6,8,9, 10, 12,13,14,16). Since Miller and Miller 1975 pointed out that in cases of increased myo - cardial infarction risk, the concentration of the high density lipo¬le~ proteins (HDL) in blood lowered. One speaks of protective factors of. HDL-Cholesterol for the heart and vessels (anti-risk factors). Miller and Miller proposed the hypothesis that this lipoprotein fraction transports cholesterol from the peripheral tissue to the liver, where it is broken down and excreted. A deficiancy in HDL would hence lead to deposition of cholesterol in the tissue of the arteries (atheroma). (7,8,12,13.) During acute myocardial infarction, what is the concentration of HDL-Cholesterol ?

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