Shiori Oshimi, - and Yuichiro Tomizawa, - and Yusuke Hirasawa, - and Toshio Honda, - and Wiwied Ekasari, - and Aty Widyawaruyanti, - and Marcellino Rudyanto, - and Gunawan Indrayanto, - and Noor Cholies Zaini, - and Hiroshi Morita, - (2008) Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A. Bioorganic and Medicinal Chemistry Letters, 18 (13). pp. 3761-3763. ISSN 0960-894X

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Abstract

A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassiarin A (3) with an unprecedented tricyclic skeleton, supporting a biogenetic pathway proposed for 3.

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