Hiroshi Morita, - and Yuta Nagakura, - and Takahiro Hosoya, - and Wiwied Ekasari, - and Aty Widyawaruyanti, - and Kanami Mori-Yasumoto, - and Setsuko Sekita, - and Yusuke Hirasawa, - (2009) Cephastigiamide A, and Antiplasmodial Activity of Cephalotaxus Alkaloids from Cephalotaxus harringtonia Forma Fastigiata. Heterocycles, 81 (2). pp. 441-450. ISSN 0385-5414
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Abstract
A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine, and homodeoxyharringtonine showed pronounced antiplasmodial activity against Plasmodium falciparum 3D7 but not against Leishmania major. Structure-activity relationship for antiplasmodial activity of isolated Cephalotaxus alkaloids was also discussed.
| Item Type: | Article | ||||||||||||||||||
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| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | ||||||||||||||||||
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| Depositing User: | Mr M. Fuad Sofyan | ||||||||||||||||||
| Date Deposited: | 30 May 2022 03:18 | ||||||||||||||||||
| Last Modified: | 02 Aug 2022 08:20 | ||||||||||||||||||
| URI: | http://repository.unair.ac.id/id/eprint/116550 | ||||||||||||||||||
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