Jun Deguchi, - and Tomoe Hirahara, - and Shiori Oshimi, - and Yusuke Hirasawa, - and Wiwied Ekasari, - and Osamu Shirota, - and Toshio Honda, - and Hiroshi Morita, - (2011) Total Synthesis of A Novel Tetracyclic Alkaloid, Cassiarin F from the Flowers of Cassia siamea. Organic Letters, 13 (16). pp. 4344-4347. ISSN 1523-7060

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Abstract

A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum in vitro, was isolated from the flowers of Cassia siamea, and its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben–Hoesch type ring construction as key steps.

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