Harisyah Manurung, - and Rita Kartika Sari, - and Wasrin Syafii, - and Umi Cahyaningsih, - and Wiwied Ekasari, - (2019) Antimalarial Activity and Phytochemical Profile of Ethanolic and Aqueous Extracts of Bidara Laut (Strychnos ligustrina Blum) Wood. Journal of the Korean Wood Science and Technology, 47 (5). pp. 587-596. ISSN 1017-0715
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Abstract
This study aimed to determine the antimalarial effect of the Strychnos ligustrina (SLW) wood extracts and to analyze its phytochemicals. The SLW powder samples were macerated with 100% ethanol (E100), 75% ethanol (E75), 50% ethanol (E50), 25% ethanol (E25), and aqueous (A100). The extracts were analyzed by LCMS/MS, and its in-vitro antimalarial activity was tested with Plasmodium falciparum. The results showed that the extract yields of E100, E75, E50, E25, and A100 were 4.3, 5.2, 5.3, 4.7, and 3.6%, respectively. The antimalarial activities of the A100, E25, E50, and E75 extracts were classified as active with IC50 values of 38.6, 42.6, 42.9, and 43.7 μg/mL, respectively. But, the antimalarial activity of the E100 extract was classified as slightly active with IC50 values of 87.4 μg/mL. The dominant compounds contained in the extracts of A100, E25, E50, E75, and E100 was the alkaloid compound, namely brucine with relative concentrations of 24.96, 24.55, 21.33, 11.79, and 11.62%, respectively.
Item Type: | Article | ||||||||||||
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Uncontrolled Keywords: | antimalarial activities, aqueous, bidara laut (Strychnos ligustrina Blum), ethanol, phytochemical profile,Plasmodium falciparum | ||||||||||||
Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms |
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Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | ||||||||||||
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Depositing User: | Mr M. Fuad Sofyan | ||||||||||||
Date Deposited: | 30 May 2022 05:47 | ||||||||||||
Last Modified: | 31 Mar 2023 08:02 | ||||||||||||
URI: | http://repository.unair.ac.id/id/eprint/116570 | ||||||||||||
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