Evaluation of cholinesterase inhibitory activity of six Indonesian Cassia species

Suciati, - and Erlinda Rhohmatul Laili, - and Debora Poerwantoro, - and Anita Probo Hapsari, - and Lailatul Zakiyah Gifanda, - and Karma Rabgay, - and Wiwied Ekasari, - and Kornkanok Ingkaninan, - (2020) Evaluation of cholinesterase inhibitory activity of six Indonesian Cassia species. Journal of Research in Pharmacy, 24 (4). pp. 472-748. ISSN 2630-6344

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Official URL: https://jrespharm.com/abstract.php?id=820

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder, which is the most common cause of dementia. The aging population means that the number of people suffering from AD is expected to increase each year if there is no effective treatment found. One of the strategies for the treatment of AD is the use of cholinesterase inhibitors. Plants have been the source of many bioactive metabolites, including cholinesterase inhibitors. The objective of this study is to investigate the potency of several plant extracts from the genus Cassia as cholinesterase inhibitors. The cholinesterase inhibitory screening was carried out against two enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), according to the modified Ellman’s method. The chemistry of the active fractions was studied by LC-MS/MS method. The results suggested that amongst six plant extracts from the genus Cassia investigated, the ethanolic extract of Cassia spectabilis showed the strongest inhibition against both AChE and BChE enzymes, with IC50 values of 39.5 and 36.9 μg/mL, respectively. Investigation on the n-hexane, ethyl acetate, and n-butanol fractions obtained from the C. spectabilis extract showed that the ethyl acetate and the n-butanol fractions gave better inhibitory activity compared to the n-hexane fraction. Based on the LC-MS/MS data, the two active fractions gave similar profile. Both fractions contained alkaloid cassine and spectaline, which may responsible for the cholinesterase inhibitory activity.

Item Type: Article
Uncontrolled Keywords: Cholinesterase inhibitor; Alzheimer’s disease ; Cassia species; Cassia spectabilis
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM
Suciati, -NIDN0004117905
Erlinda Rhohmatul Laili, --
Debora Poerwantoro, --
Anita Probo Hapsari, --
Lailatul Zakiyah Gifanda, --
Karma Rabgay, --
Wiwied Ekasari, -NIDN0022016902
Kornkanok Ingkaninan, --
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 30 May 2022 06:30
Last Modified: 28 Apr 2023 00:59
URI: http://repository.unair.ac.id/id/eprint/116573
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