Alfinda Novi Kristanti*, .- and Ei Ei Aung, .- and Nanik Siti Aminah, .- and Yoshiaki Takaya, .- and Hnin Thanda Aung, .- and Rico Ramadhan, .- (2022) Bioactive triterpenoids from Indonesian medicinal plant Syzygium aqueum. Open Chemistry, 20 (1). pp. 204-211. ISSN 23915420

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Abstract

A large common species, Syzygium aqueum, belonging to the genus Syzygium possesses numerous bioactive phytochemical constituents. Moreover, the different parts of this species have been used as folk medicine since centuries ago. In this study, a phytochemical exploration was carried out on the plant’s stem bark. Isolation of the compounds was carried out through the extraction step with some organic solvents, followed by separation and purification using chromatography techniques until the two triterpenoids were isolated from nonpolar and semipolar extracts. Structure elucidation was done using spectroscopic methods. These compounds were identified as alphitolic acid and arjunolic acid. Subsequently, these two compounds were used in anticancer tests against human cancer cells HeLa, T47D, and A549 using colorimetric assay. The result showed that both compounds showed more inhibition of the growth of HeLa and T47D than A549 cancer cells, with the highest activity shown by arjunolic acid against HeLa cell lines.

Item Type:	Article
Uncontrolled Keywords:	Syzygium aqueum ; alphitolic acid; arjunolic acid; MTT assay; XTT assay
Subjects:	Q Science Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	08. Fakultas Sains dan Teknologi > Kimia
Creators:	Creators NIM Alfinda Novi Kristanti*, .- UNSPECIFIED Ei Ei Aung, .- UNSPECIFIED Nanik Siti Aminah, .- UNSPECIFIED Yoshiaki Takaya, .- UNSPECIFIED Hnin Thanda Aung, .- UNSPECIFIED Rico Ramadhan, .- UNSPECIFIED
Depositing User:	Mr Vega Andi Budiman
Date Deposited:	09 Jun 2022 02:24
Last Modified:	09 Jun 2022 02:24
URI:	http://repository.unair.ac.id/id/eprint/116677
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