Andra Rizqiawan, - and Obed Aprilia, - and Retta Gabriella Pakpahan, - and Essy Rodherika, - and Ayu Setyowati, - and Tobiumei Kei, - (2021) Application of Mangosteen Peel Extract (Garcinia Mangostana Linn.) to TGF-1, PDGF-B, FGF-2 and VEGF-A Expression on Human Gingival Fibroblast Cell Culture (In Vitro Study). Journal of International Dental and Medical Research, 14 (1). pp. 119-124. ISSN 1309-100X

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Abstract

Wound healing is a complex and dynamic process. Growth factors such as TGF-1, PDGF-B, FGF-2, and VEGF-A, act as chemotactic macrophages in the wound healing process. These proteins increase the proliferation of fibroblasts, which plays an important role in the wound healing process. Mangosteen peel pericarp (MPP) contains tannin, saponin, flavonoid, and xanthone, which function as antioxidants, anti-inflammatories, and antimicrobials increasing the proliferation of fibroblasts and accelerating wound healing. Analyze the effect of MPP on TGF-β1, PDGF-B, FGF-2, and VEGF-A’s expression on human gingival fibroblasts. This research used a 24 and 48-hour control and a treatment group where MPP was given for periods of 24 and 48 hours. The data was processed by PCR assay with gel electrophoresis. During the 24 and 48-hour treatment period, TGF-β1 and VEGF-A showed a brighter band than the control. After 24 hours of treatment, FGF-2 showed a brighter band than the 24-hour control. There was no increased expression of FGF-2 in the 48-hour treatment period compared to the 48-hour control. PDGF-B in both the 24 and 48-hour control showed a brighter band than the 24 and 48-hour treatment. MPP increases the expression of TGF-β1, FGF-2, and VEGF-A and decreases the expression of PDGF-B on human gingival fibroblasts.

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