Surya Atmajaya, - and Dion Sandro Satrya, - and Retno Kathiningsih, - and Andra Rizqiawan, - (2019) Snakehead Fish Extract (Channa Striata) Increase The Number Of Fibroblasts Cells Post Extraction Tooth In Wistar Rats (Rattus Norvegiccus). Biochemical and Cellular Archives, 19. pp. 4863-4866. ISSN 0972-5075

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Abstract

Tooth extraction is an invasive action which causes dental tissue traumatic injury. The regeneration process is divided into four phases namely hemostasis, inflammatory, proliferating and remodeling. Fibroblast cells play important roles in the proliferating phase, with the ability to hasten wound healing using snakehead fish. This (Channa striatta) contains albumin, Zn, Fe, Mg, Cu and unsaturated fatty acids as sources of nutrition which is beneficial to wound healing by increasing fibroblast cells. The objective of this research is to determine the effect of snakehead fish extract against the number of fibroblast in wound healing post extraction of Wistar rats. A total of 24 Wistar rats were divided into the control and treatment groups, with each further divided into three subgroups. On the 3rd, 5th and 7th day, they were histologically processed with HE staining. The statistical analysis showed significant differences between the control and treatment group. The extract of snakehead fish with a concentration of 100% increases the number of fibroblasts during tooth extraction in Wistar rats.

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