Wita Kartika Nurani, - and Gatot Soegiarto, - and Yuliasih, - (2021) Natural Killer Cell in Mild and Severe Systemic Lupus Erythematosus. Journal of International Dental and Medical Research, 14 (4). pp. 1736-1742. ISSN 1309-100X

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by acute relapses that affect numerous organ systems. The purpose of this study was to compare the number of natural killer (NK) cells and the proportion of activated NK cells in patients with mild and severe SLE based on CD69 expression. The design of this study was cross-sectional. Patients with SLE in this study were patients who met four criteria out of 11 criteria for the 1997 ACR. Patients were examined for the number of NK cells, the percentage of activated NK cells, and SLE disease activity assessed by the Score Systemic Lupus Activity Measure (SLAM) index. All patients were female, 17 patients in the mild SLE group (47.2%) and 19 patients in the severe SLE group (52.8%). The mean age of the SLE group was 30.76 ± 10.146 years, and the severe SLE group included 27.89 ± 7.527 years. In this study, the mean body mass index (BMI) in the mild SLE group was 20.859 ± 2.3203 kg/m2, while BMI in the severe SLE group was 21.900 ± 3.1213 kg/m2. The mean number of NK cells in the mild SLE group (161.94 ± 113.004 cells/µL) was higher than the severe SLE group (63.16 ± 54.851 cell/µL) (p = 0.006). The mean percentage of activated NK cells in the severe SLE group (4.00 ± 3.45cells/µL) was higher than the mild SLE group (1.90 ± 0.94cells/µL) (p = 0.141). There was a significant difference in the number and percentage of activated NK cells between the mild SLE group and the severe SLE group.

Item Type:	Article
Uncontrolled Keywords:	Systemic lupus erythematosus, NK cell, autoimmune, immunology
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Wita Kartika Nurani, - UNSPECIFIED Gatot Soegiarto, - NIDN8888210016 Yuliasih, - NIDN8891010016
Depositing User:	arys fk
Date Deposited:	14 Jun 2022 04:15
Last Modified:	14 Jun 2022 04:15
URI:	http://repository.unair.ac.id/id/eprint/116752
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