Risma Aprinda Kristanti, - and Taufan Bramantoro, - and Pratiwi Soesilawati, - and Erni Maduratna Setiawatie, - and Bambang Purwanto, - (2021) Periodontitis Affects Skeletal Muscle Metabolism Through an Increase in Proinflammatory Cytokines. Journal of International Dental and Medical Research, 14 (4). pp. 1623-1628. ISSN 1309-100X

	Text (NASKAH) Periodontitis Affects Skeletal Muscle Metabolism Throught.pdf Download (183kB)
	Text (TURNITIN) 17. Periodontitis Affects Skeletal Muscle Metabolism Through an Increase in Proinflammatory Cytokines.pdf Download (2MB)
	Text (VALIDASI) 17.Dr.Pratiwi (Periodontitis Affects Skeletal...).pdf Download (951kB)

Abstract

Periodontitis is an inflammatory disease of the oral cavity which attacks the gingival and periodontal tissue. One of the results of immune response activity in periodontitis is an increase in proinflammatory cytokines both locally and systematically. An increase in proinflammatory cytokines will affect tissue metabolism, including skeletal muscle tissue. The mechanism of periodontitis in affecting skeletal muscle is still being discussed and studied, this review will discuss the mechanism of periodontitis in affecting skeletal muscle metabolism. The interaction between bacteria and the immune system in periodontal tissues will activate the immune system and can cause an increase in proinflammatory cytokines such as IL-6, IL-1β, and TNF-α both locally and systemically. The presence of bacteria in the body's circulation and an enhancement of proinflammatory cytokines systemically can affect other tissues in the body, one of which is skeletal muscle. Several researchers have proven that periodontitis affects the regeneration process, glucose uptake, and recovery in skeletal muscle. An increase in IL-6, IL-1β, and TNF-α caused by periodontitis can reduce the process of muscle regeneration, reduce glucose uptake in skeletal muscle, and decreases the level of muscle responsiveness to training loads.

Actions (login required)

View Item