Agung Satria Wardhana, - and Intan Nirwana, - and Hendrik Setia Budi, - and Meircurius Dwi Condro Surboyo, - (2021) Role of Hydroxyapatite and Ellagic Acid in the Osteogenesis. European Journal of Dentistry, 15 (1). pp. 8-12. ISSN 1305-7456

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Abstract

Objective Ellagic acid (EA), a phenolic antioxidant, has benefits in bone health and wound healing. The combination of EA and hydroxyapatite (HA) (EA-HA) is expected to increase osteogenesis. The aim of this study was to analyze osteogenesis after appli-cation of EA-HA according to the number of osteoblasts and osteoclasts in the bone and the expression of the receptor activator of nuclear factor kappa- ligand (RANKL), osteoprotegerin (OPG), and osteocalcin (OCN) protein. Materials and Methods Thirty Wistar rats were assessed with bone defects created in the left femur. The defects were filled with EA-HA and then sutured. Control groups were filled with polyethylene glycol (PEG) or HA. Each group was sacrificed either 7 or 14 days after treatment. Results The defects filled with EA-HA exhibited the highest number of osteoblasts and the greatest expression of OPG and OCN at both day 7 and day 14 (p = 0.000). Conversely, treatment with EA-HA resulted in lower numbers of osteoclasts and reduced RANKL staining at both time points (p = 0.000). Conclusions EA-HA can increase osteogenesis in bone defects by increasing the number of osteoblasts and the expression of OPG and OCN.

Item Type:	Article
Uncontrolled Keywords:	osteogenesis,hydroxyapatite,ellagic acid,osteocalcin,RANKL, OPG
Subjects:	R Medicine R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions:	02. Fakultas Kedokteran Gigi > Oral Biology
Creators:	Creators NIM Agung Satria Wardhana, - - Intan Nirwana, - NIDN0030045702 Hendrik Setia Budi, - NIDN0010067204 Meircurius Dwi Condro Surboyo, - NIDN0030059010
Depositing User:	Muhammad Fadli Rois
Date Deposited:	04 Jul 2022 06:21
Last Modified:	20 Apr 2023 04:44
URI:	http://repository.unair.ac.id/id/eprint/116938
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