Takahiro Hosoya, - and Fumie Yamasaki, - and Asami Nakata, - and Abdul Rahman, - and Idha Kusumawati, - and Noor Cholies Zaini, - and Hiroshi Morita, - (2011) Inhibitors of Nitric Oxide Production from Stemona javanica. Planta Medica, 77 (3). pp. 256-258. ISSN 1439-0221

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Abstract

In our screening program for bioactive natural products from our library of tropical plants, the extract prepared from the roots of Stemona javanica inhibited NO production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide (LPS). Bioassay-guided fractionation of the extract from S. javanica led to the isolation of two active compounds, stemofoline (1) and stemanthrene C (2). The inhibition mechanism of 1 was proposed to suppress iNOS expression in J774.1 cells stimulated by LPS, whereas that of 2 was due to potent radical scavenging activity resulting in NO inhibitory activity.

Item Type:	Article
Uncontrolled Keywords:	Stemonajavanica, Stemonaceae, stemofoline, stemanthrene C, iNOS, DPPH radical scavenge
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:	Creators NIM Takahiro Hosoya, - - Fumie Yamasaki, - - Asami Nakata, - - Abdul Rahman, - - Idha Kusumawati, - NIDN0004087003 Noor Cholies Zaini, - - Hiroshi Morita, - -
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	08 Jul 2022 02:05
Last Modified:	26 Mar 2023 07:47
URI:	http://repository.unair.ac.id/id/eprint/116994
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