Kazumasa Zaima, - and Tomoko Hirata, - and Takahiro Hosoya, - and Yusuke Hirasawa, - and Koichiro Koyama, - and Abdul Rahman, - and Idha Kusumawati, - and Noor Cholies Zaini, - and Motoo Shiro, - and Hiroshi Morita, - (2009) Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa. Journal of Natural Product, 72 (9). pp. 1686-1690. ISSN 0163-3864

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Abstract

Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma−iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma−aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.

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