Cempaka Thrusina, - and Hanik Badriyah Hidayati, - and Yudiyanta, - and Irfan Pranowo, - and Vania Ayu Puspamaniar, - (2022) The role of platelet rich plasma in knee joint pain. Anaesth, Pain & Intensive Care, 26 (3). pp. 405-409. ISSN 1607-8322

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Abstract

Osteoarthritis (OA) is a joint disorder is common worldwide. Pain and loss of function are the main clinical sign in knee joint OA that could come from periosteal nerve stretches, intraosseal hypertension, joint capsule stretches, intra-articular hypertension, ligament stretches, subchondral bone micro fracture, bursitis, and muscle spasm. Current therapy approach focuses on preventing progression and reducing symptoms by using a non-invasive procedure. Non-operative therapeutic intervention, that involves intra-articular injection in the knee joints, plays an important role in OA management. Platelet rich plasma (PRP) is a plasma fraction that contains concentrated platelets, has an autologue growth factor and high concentration of proteins that could improve healing process at cellular, tendon, ligament, muscle, as well as bone related tissue injury. Growth factor contained in PRP is responsible for anti-inflammatory effect through its inhibitory effect on Nuclear factor-kB (NFkB) cascade, thus it inhibits the inflammatory mediator production along with decreased COX2 expression. Roles of PRP towards NFkB deactivation could decrease chondrocyte inflammation, restore anabolic activity, and inhibit monocyte migration that could prevent OA progressivisity and reduce pain. PRP pathophysiology mechanism in healing process has made PRP an option for pain management in knee joint OA. Abbreviations: OA- Osteoarthritis; PRP - Platelet rich plasma; NFkB - Nuclear factor-kB; COX2 - Cyclooxygenase-2; HGF – Hepatocyte growth factor; TGF-β - Transforming growth factor-β; IGF - Insulin-like growth factor; PDGF - Platelet-derived growth factor; FGF - Fibroblast growth factor; EGF - Epidermal growth factor; VEGF - Vascular endothelial growth factor.

Item Type:	Article
Uncontrolled Keywords:	Osteoarthritis knee joint, Platelet rich plasma, Nuclear factor-κB (NFkB), Human, Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Neurologi (Spesialis)
Creators:	Creators NIM Cempaka Thrusina, - UNSPECIFIED Hanik Badriyah Hidayati, - NIDN0024097808 Yudiyanta, - UNSPECIFIED Irfan Pranowo, - UNSPECIFIED Vania Ayu Puspamaniar, - UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	22 Aug 2022 04:25
Last Modified:	22 Aug 2022 04:25
URI:	http://repository.unair.ac.id/id/eprint/117657
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