Tavia Cesarin Prastari, 051111232 (2015) Perbandingan Persentase Hasil Sintesis antara N-Benzilidenisonikotinohidrazida dengan N-(2-Metoksibenzjliden)Isonlkotinohidrazlda dari Isoniazida. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

In this research, the author synthesized N-benzylideneisonicotinohydrazide and N -(2-methoxybenzylidene )isonicotinohydrazide. The obtained yield of products would be compared (with the same condition). Reaction mechanism of this synthesis is nucleophilic addition by eliminating water. Methoxy group at 2-methoxybenzaldehyde caused hindrance effect and made it is more difficult to be attacked by a nucleophile. The structure of the products were identified by UV spectrophotometry, IR spectrophotometry, and IH_NMR spectrometry. The N-benzylideneisonicotinohydrazide is produced as white crystal with 98.32% yield and N-(2-methoxybenzylidene)isonicotinohydrazide is produced as white crystal with 66.52% yield. As conclusion, synthesis of Nbenzylideneisonicotinohydrazide gave yield higher than N-(2-methoxybenzylidene )isonicotinohydrazide.

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