Drug Hypersensitivity in Daily Practice Repository

Drug Hypersensitivity in Daily Practice

Gatot Soegiarto, - (2019) Drug Hypersensitivity in Daily Practice. Qanun Medika : Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 3 (2). pp. 93-111. ISSN 25489526

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Official URL: http://journal.um-surabaya.ac.id/index.php/qanunme...

Abstract

Adverse drug reactions can affect up to 25% of outpatients and 10–20% of hospitalized patients. They are an important public health issue due to the potential of fatal outcomes. They are increasingly common in daily practice, but ascertaining whether the adverse reaction is a true allergic reaction to the drug is not easy. Drug hypersensitivity encompasses a spectrum of immunologically and non-immunologically-mediated reactions with varying mechanisms and clinical presentations. Factors associated with an increased risk of developing a drug hypersensitivity include patient-related factors, treatment regimen-related factors, and drug-related factors. Diagnosis of drug hypersensitivity relies on a careful history and physical examination and, in some instances, in vivo and in vitro testing and drug provocation tests. The most effective strategy for the management of drug allergy is avoidance and discontinuation of the offending drug(s). Alternative medications with unrelated chemical structures should be given. Additional therapy is largely supportive which includes nutritional support, fluid replacement, and symptomatic which may include topical corticosteroids, oral antihistamines and, in severe cases, systemic corticosteroids. This article will discuss the classification of adverse reactions to drugs, professional steps that can be taken by a physician in prescribing drugs, minimizing the risk of adverse drug reactions, approach to diagnosis, and managing drug hypersensitivity cases in daily practice.

Item Type:

Article

Uncontrolled Keywords:

Immunology, Medicine, Drugs

Subjects:

R Medicine > R Medicine (General)
R Medicine > RC Internal medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Dalam

Creators: