Balqis Afifah, - and Soeharsono, - and Imam Mustofa, - and Kuncoro Puguh Santoso, - and Jola Rahmahani, - and Arif Nur Muhammad Ansori, - and Reviany Vibrianita Nidom, - and Astria Novitasari Nidom, - and Muhammad Khaliim Jati Kusala, - and Dhani Prakoso, - and Nor Laela Ramadhaniyah, - (2022) Interferon-Gamma Profile of Mice (Mus musculus L.) after Complete SARS-CoV-2 Vaccination. International Journal of Health Sciences, 6 (2). pp. 5030-5038. ISSN 2550-6978, E-ISSN 2550-696X

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) have afflicted millions of people in a worldwide pandemic. Several vaccines have been developed to prevent infection and illness. The success of preventing and controlling the COVID-19 by using an effective and efficient vaccine. This study aimed to find out the profile of interferon-gamma (IFN-γ) after COVID-19 vaccination. This study conducted at Animal Laboratory Professor Nidom Foundation (ABSL-3) from December 2021 to February 2022. The present study is an experimental study with a post test only control group design using 90 mice (Mus musculus L.). The test group consisted of mice injected subcutan with 0.1 mL PBS (P1), 0.1 mL adjuvant 1 (P2), 0.1 mL adjuvant 2 (P3), 0.1 mL VLPs SARS-CoV-2 10 μg (P4), 0.1 mL VLPs SARS-CoV-2 dose 50 μg (P5), 0.1 mL VLPs SARS-CoV-2 10 μg + adjuvant 1 (P6), 0.1 mL VLPs SARS-CoV-2 10 μg + adjuvant 2 (P7), 0.1 mL VLPs SARS-CoV-2 50 μg + adjuvant 1 (P8), and 0.1 mL VLPs SARS-CoV-2 50 μg + adjuvant 2 (P9). The data analysed by using ANOVA Keywords : COVID-19, virus-like particles, adjuvant, IFN-γ, IgG

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